Ko te Patient Rheumatoid Arthritis i te Rituxan Study i whakawhanakehia te Putea Nui o PML
Ko te mate kino o te PML (te leukoencephalopathy multifocal progressive) kua tohua i roto i te mate pukupuku rhumatoid (RA) i uru ki te whakamatautau haumanu whakamau mo Rituxan (rituximab). No reira, kua tukuna e te FDA me te kaiwhakanao o te tarukino te whakatupato me te whakahou i a Rituxan hei whakaatu i nga korero hei whakauru i te PML.
He aha te PML?
Ko te PML hoki e mohiotia ana ko te leukoencephalopathy multifocal progressive.
E ai ki te National Institute of Neurological Disorders and Stroke, "Ko te leukoencephalopathy multifocal (PML) te nekehanga mai i te whakaohotanga o te huaketo noa i roto i te pūnaha taiao matua o te tangata takitahi. ko te nuinga o nga tangata, kaore i te kino, engari i roto i nga hunga e whakaitia ana i te parekura. "
Kei te mohiotia ake mo te Patai RA I whakawhanake i te PML?
I mua i te mate a te RA i te whakawhanake i tetahi mate mate mate JC me PML. I mate te mate o PML i te 18 marama i muri i te wa i whiwhi ai te kaitautoko i te hohenga whakamutunga o Rituxan i roto i te ako whakawhitinga haumaru.
I whakawhanakehia hoki e te kaitautoko RA te mate pukupuku oropauryngeal ( mate pukupuku korokoro ), a ka tukinotia ki te chemotherapy me te raamati 9 marama i mua i te whakawhanake PML. Ko te kaitautoko he mahinga hauora uaua kua kaha ki te whakawhanake i te PML. I tua atu i te RA, he mate te mate o Sjogren, me te tino taumata C4.
I tukinotia te kaitautoko ki te hangarau, te taakaero, me te mate TNF i mua i te tukinotanga ki a Rituxan. I whakamahia ano hoki te tikanga me te steroids i te wa i muri i te maimoatanga rituximab.
He aha te FDA e whakautu ana ki te Pire PML?
Kei te arotake ano te FDA i nga tohutohu tohutohu me te whakamöhio i nga tohunga hauora i roto i tetahi reta me te iwi katoa i runga i tana paetukutuku mo te take mate o PML.
He aha Me Nga Tangata Kaimahi I Rituxan?
Kia rite tonu ki nga wa katoa, matapakihia e koe taau toha ki to taau Kei te tohutohu nga tohunga kei te whakawhanaketia e te kaitautoko he tohu tohu neurologic - me whakaarohia he korero ki te neurologist, te MRI roro, me te pupuhi ngota. Ko nga mate e whakawhanake ana i te PML me mutu te Rituxan, ka mutu, ka whakaiti ranei i etahi atu aa-mate-a-tinana, i te wa e whakaarohia ana te rongoā anti-viral. Engari, kaore he maimoatanga ka taea te whakatau i te PML ki te whakawhanake.
Kaupapa:
FDA: He ahua nui o Te Progressive Multifocal Leukoencephalopathy i te Patient Receiving Rituximab. Te Karere Arataki a te Doctor . Mahuru 11, 2008.
FDA Medwatch. Nga korero Haumaru Nui Nui mo te Hauora Leukoencephalopathy Me Te Whakamahinga o Rituxan. Mahuru 11, 2008.